3-(4-甲氧基苯基)-1-苯丙酮合成路线 （共 30 条）
反应条件
potassium carbonate in methanol
T=60°C; 6 h;
参考文献
Iman, Manoutcher; Bouyssou, Pascal; Chenault, Jacques
Synthesis, 1990 , # 7 p. 631 - 632
反应条件
1: 4-methoxy-benzaldehyde With TMSC(Li)N2 in tetrahydrofuran; hexane
T=-78 - 20°C; 1.5 h;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
3: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane
T=20°C; 1 h; Further stages.;
参考文献
Hari, Yoshiyuki; Date, Koji; Aoyama, Toyohiko
Heterocycles, 2007 , vol. 74, # C p. 545 - 552
反应条件
manganese(IV) oxide in acetone
T=20°C; 5 h;
参考文献
Shankar, Ravi; Chakravarti, Bandana; Singh, Uma Sharan; Ansari, Mohd. Imran; Deshpande, Shreekant; Dwivedi, Shailendra Kumar Dhar; Bid, Hemant Kumar; Konwar, Rituraj; Kharkwal, Geetika; Chandra, Vishal; Dwivedi, Anila; Hajela
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 11 p. 3847 - 3856
反应条件
1: magnesium / diethyl ether / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 2 h / Reflux
View Scheme
参考文献
Zhou, Jun; Zhang, Guang-Liang; Zou, Jian-Ping; Zhang, Wei
European Journal of Organic Chemistry, 2011 , # 19 p. 3412 - 3415
反应条件
triethylamine; magnesium chloride in acetonitrile
T=20°C; 1 h;
参考文献
Soltanirad, Mohammad Navid; Behrouz, Somayeh
Synlett, 2011 , # 17 p. 2562 - 2566
反应条件
1: magnesium / diethyl ether / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 2 h / Reflux
View Scheme
参考文献
Zhou, Jun; Zhang, Guang-Liang; Zou, Jian-Ping; Zhang, Wei
European Journal of Organic Chemistry, 2011 , # 19 p. 3412 - 3415
反应条件
1: 73 percent / NaH / dimethylsulfoxide / 3 h / 55 °C
2: 65 percent / aq. H2SO4 / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Mangelinckx, Sven; Rooryck, Stijn; Jacobs, Jan; De Kimpe, Norbert
Tetrahedron Letters, 2007 , vol. 48, # 37 p. 6535 - 6538
反应条件
1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 74 percent / tetrahydrofuran; hexane / 25 h / -78 - 20 °C
2.1: 73 percent / NaH / dimethylsulfoxide / 3 h / 55 °C
3.1: 65 percent / aq. H2SO4 / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Mangelinckx, Sven; Rooryck, Stijn; Jacobs, Jan; De Kimpe, Norbert
Tetrahedron Letters, 2007 , vol. 48, # 37 p. 6535 - 6538
反应条件
1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 74 percent / tetrahydrofuran; hexane / 25 h / -78 - 20 °C
2.1: 73 percent / NaH / dimethylsulfoxide / 3 h / 55 °C
3.1: 65 percent / aq. H2SO4 / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Mangelinckx, Sven; Rooryck, Stijn; Jacobs, Jan; De Kimpe, Norbert
Tetrahedron Letters, 2007 , vol. 48, # 37 p. 6535 - 6538
反应条件
1: 84 percent / I2, K2CO3 / methanol / 1) 0 - 5 deg C, 2h, 2) RT, 4h
2: 60 percent / K2CO3 / methanol / 6 h / 60 °C
View Scheme
参考文献
Iman, Manoutcher; Bouyssou, Pascal; Chenault, Jacques
Synthesis, 1990 , # 7 p. 631 - 632
