反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 5 min, 2.) THF, -78 deg C, 5 min
2: n-Bu4NI / dimethylformamide / 24 h / 80 °C
3: Dibal-H / toluene / 2 h / -78 deg C -> 0 deg C
4: HCl(g)
5: 1.) Wang resin, Huenig's base, 2.) 3percent Pd(PPh3)4, 2M Na2CO3, 3.) ICl, Et3N / 1.) DMF, 40-50 deg C, 2.) DME, reflux, 3.) DMF, 80-90 deg C, 24 h
View Scheme
参考文献
Han, Yongxin; Walker, Shawn D.; Young, Robert N.
Tetrahedron Letters, 1996 , vol. 37, # 16 p. 2703 - 2706
