(R)-(+)-α-甲氧基-α-(三氟甲基)苯乙酸合成路线 (共 31 条)
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile T=55°C; 4 h;
参考文献
Moreno-Dorado, F. Javier; Guerra, Francisco M.; Ortega, Maria J.; Zubia, Eva; Massanet, Guillermo M.
Tetrahedron Asymmetry, 2003 , vol. 14, # 4 p. 503 - 510
反应条件
in dimethylsulfoxide-d6; N,N-dimethyl-formamide T=37°C; 48 h;
参考文献
US7741513 B2, ;
Page/Page column 19-20 ;
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=20°C; 12 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 10 p. 1274 - 1284
反应条件
potassium hydroxide in water 5 h; Heating;
参考文献
Ohta, Hiromichi; Miyame, Yoshitaka; Kimura, Yoichi
Chemistry Letters, 1989 , p. 379 - 380
参考文献
Journal of the American Chemical Society, , vol. 92, p. 875 - 886
反应条件
2: Ag2O 3: aq. H2SO4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 92, p. 875 - 886
反应条件
1: Ag2O 2: aq. H2SO4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 92, p. 875 - 886
反应条件
1: With (1S,2R)-1-aminoindan-2-ol in ethanol; ethyl acetate T=30°C; Addition; 12 h; 2: With hydrogenchloride Hydrolysis; Further stages.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 1 p. 111 - 119
反应条件
1: 90 percent 2: hydrolysis View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 36, # 8 p. 499 - 504
反应条件
trifluorormethanesulfonic acid T=125°C; 0.5 h;
参考文献
Synlett, , # 11 p. 1886 - 1888