(3R,4S)-1-(4-氟苯基)-2-氧代-4-[4-(苄氧基)苯基]-3-氮杂环丁烷丙酸甲酯合成路线 （共 11 条）
反应条件
1: LiOH*H2O / methanol / 2 h 2: oxalyl chloride / CH2Cl2 / 16 h / 22 °C 3: (Ph3P)4Pd / tetrahydrofuran / 1 h / 10 °C 4: BH3*Me2S / tetrahydrofuran / 3 h / 22 °C 5: H2 / 10percent Pd/C / ethanol / 16 h / 3102.9 Torr View Scheme
参考文献
Rosenblum, Stuart B.; Huynh, Tram; Afonso, Adriano; Davis Jr., Harry R.; Yumibe, Nathan; Clader, John W.; Burnett, Duane A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 973 - 980
