1-(4-氯-苯基)-2,5-二甲基-1H-吡咯-3-甲醛合成路线 （共 3 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=20°C; 0.25 h; Inert atmosphere; 2: 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole T=100°C; Vilsmeier-Haack Formylation; 3 h; Inert atmosphere;
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / |Microwave irradiation 2.1: trichlorophosphate / 0.25 h / 20 °C / |Inert atmosphere 2.2: 3 h / 100 °C / |Inert atmosphere View Scheme
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / |Microwave irradiation 2.1: trichlorophosphate / 0.25 h / 20 °C / |Inert atmosphere 2.2: 3 h / 100 °C / |Inert atmosphere View Scheme
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
