2,3,5-三甲基苯甲醚合成路线 （共 26 条）
反应条件
potassium hydroxide; sodium acetate; trichlorophosphate in N-methyl-acetamide; ethanol; water; benzene
参考文献
Hoffmann-La Roche Inc.
Patent: US4021574 A1, 1977 ;
反应条件
tin(IV) chloride Formylation;
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1: 95 percent / SnCl4 2: 100 percent View Scheme
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1: MgSO4, BF3*Et2O / 1 h / 5 °C 2: 1.) 1.5 M BuLi / 1.) THF/hexane, -30 deg C, 2.) THF/hexane, 2 h, room temperature 3: 97 percent / hydrogen / Lindlar-catalyst, 1,2-bis<(2-hydroxyethyl)thio>ethane / ethanol / 4 h / Ambient temperature 4: 65 percent / TsOH*H2O / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Soukup; Broger; Widmer
Helvetica Chimica Acta, 1989 , vol. 72, # 2 p. 370 - 376
反应条件
1: glacial acetic acid; nitric acid / 30 °C 2: tin; aq.-ethanolic hydrochloric acid View Scheme
参考文献
John; Rathmann
Chemische Berichte, 1940 , vol. 73, p. 995,999
反应条件
1: 72.5 percent / chlorosulfonic acid / CH2Cl2 / -10 - -5 °C 2: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate 3: 1.) 0.2 N H2SO4, 2.) hydrogen / 2.) palladium black / 1.) ethyl acetate, 2.) methanol View Scheme
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831
反应条件
1: 72.5 percent / chlorosulfonic acid / CH2Cl2 / -10 - -5 °C 2: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate View Scheme
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831
反应条件
chlorosulfonic acid in dichloromethane T=-10 - -5°C;
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831
反应条件
1: 95 percent / SnCl4 2: 100 percent 3: 83 percent 4: 99 percent / LiAlH4 View Scheme
参考文献
Pharmaceutical Research, , vol. 12, # 7 p. 983 - 992
反应条件
1: 95 percent / SnCl4 2: 100 percent 3: 83 percent View Scheme
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
