2,3,5-三甲基苯甲醚合成路线 （共 26 条）
反应条件
1: 95 percent / SnCl4
2: 100 percent
3: 83 percent
4: 99 percent / LiAlH4
5: 20 percent / MnO2
View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
反应条件
1: MgSO4, BF3*Et2O / 1 h / 5 °C
2: 1.) 1.5 M BuLi / 1.) THF/hexane, -30 deg C, 2.) THF/hexane, 2 h, room temperature
3: 97 percent / hydrogen / Lindlar-catalyst, 1,2-bis<(2-hydroxyethyl)thio>ethane / ethanol / 4 h / Ambient temperature
4: 13 percent / TsOH*H2O / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Soukup; Broger; Widmer
Helvetica Chimica Acta, 1989 , vol. 72, # 2 p. 370 - 376
反应条件
hydrogenchloride; aluminium trichloride in dichloromethane
参考文献
Schering Aktiengesellschaft
Patent: US4006241 A1, 1977 ;
反应条件
1: 1.) POCl3 / 1.) 10-20 deg C, 15 min., 2.) 110 deg C, 6 h
2: 74.6 percent / aq. NaOH / 7 h / 20 - 25 °C
3: 85 percent / H2 / Raney Ni / ethanol / 760 Torr
View Scheme
参考文献
Samokhvalov, G. I.; Zakharova, N. I.; Sokolova, N. N.; Filippova, T. M.; Raigorodskaya, O. I.; et al.
Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 5 p. 343 - 348
Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 5 p. 43 - 47
反应条件
1.1: POCl3 / 1 h
1.2: 63 percent / 24.5 h / 0 - 20 °C
2.1: 75 percent / NaOH / H2O / 24 h
View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
反应条件
1: 1.) POCl3 / 1.) 0 deg C, 2 h, 2.) 70 deg, 24 h
2: 93 percent / LiAlH4
3: 95 percent / 38 percent HCl / methanol; H2O / 96 h / Ambient temperature
View Scheme
参考文献
Bestmann; Ermann
1984 , vol. 1984, # 10 p. 1740 - 1745
