1-溴-3,5-二甲氧基苯合成路线 （共 64 条）
反应条件
ammonia; sodium; iron nitrate (III)
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 25, p. 294 - 300
反应条件
boron tribromide in dichloromethane T=0 - 20°C; 18 h;
参考文献
Guo, Jing; Zhuang, Jiaming; Wang, Feng; Raghupathi, Krishna R.; Thayumanavan
Journal of the American Chemical Society, 2014 , vol. 136, # 6 p. 2220 - 2223
反应条件
iodine; tert.-butyl lithium in tetrahydrofuran; pentane T=-78 - 20°C;
参考文献
Alberico, Dino; Rudolph, Alena; Lautens, Mark
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 775 - 781
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Merck Patent Gesellschaft Mit Beschrankter Haftung
Patent: US2012/138865 A1, 2012 ;
反应条件
ammonia; sodium; iron(III) chloride
参考文献
Kametani,T. et al.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 1032 - 1043
反应条件
iodine; magnesium in tetrahydrofuran 3 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED; BERDINI, Valerio; ANGIBAUD, Patrick René; WOODHEAD, Steven John; SAXTY, Gordon
Patent: WO2013/61074 A1, 2013 ;
Location in patent: Page/Page column 159 ;
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II); 1,3-bis-(diphenylphosphino)propane; triethylamine in toluene T=100°C; 18 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 10, # 12 p. 2597 - 2600
反应条件
1: trichlorophosphate / 1 h / 0 - 100 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation View Scheme
参考文献
ANACOR PHARMACEUTICALS, INC.; GLAXOSMITHKINE LLC; XIA, Yi; ALLEY, Michael, Richard Kevin; ZHOU, Yasheen; SINGH, Rajeshwar; DING, Charles; CAO, Kathy; PLATTNER, Jacob, J.; OU, Ligong; JIA, Guofeng; SARASWAT, Neerja; RAMACHANDRAN, Sreekanth; ZHOU, Ding
Patent: WO2011/17125 A1, 2011 ;
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether T=0 - 20°C; 6 h;
参考文献
Rempel, Viktor; Volz, Nicole; Hinz, Sonja; Karcz, Tadeusz; Meliciani, Irene; Nieger, Martin; Wenzel, Wolfgang; Braese, Stefan; Mueller, Christa E.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 7967 - 7977
反应条件
1: 1,1-dimethylethylmagnesium chloride With bis(acetylacetonate)nickel(II); 1-(2-carboxyethyl)-3-mesityl-1H-imidazol-3-ium chloride; lithium tert-butylate in tetrahydrofuran T=0°C; 0.166667 h; Inert atmosphere; 2: 1-bromo-3,5-dimethoxybenzene in tetrahydrofuran T=0 - 20°C; Kumada-Corriu-Tamao type reaction; Inert atmosphere;
参考文献
Lohre, Claudia; Droege, Thomas; Wang, Congyang; Glorius, Frank
Chemistry - A European Journal, 2011 , vol. 17, # 22 p. 6052 - 6055
