4-氟-2-甲氧基苯甲酸甲酯合成路线 （共 14 条）
反应条件
thionyl chloride T=0°C; 12 h;
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
Location in patent: Paragraph 00254; 00255 ;
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) 18 h;
参考文献
US2004/220194 A1, ;
Page 35 ;
US 20040220194 A1
反应条件
potassium carbonate in acetone 2 h; Heating;
参考文献
Corona, L Del; Signorelli, G; Pinzetta, A; Coppi, G
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 419 - 425
参考文献
WO2005/80359 A1, ;
Page/Page column 109 ;
WO 2005/080359 A1
反应条件
potassium tert-butylate in 1,4-dioxane T=40°C; Inert atmosphere; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 50, # 27 p. 3776 - 3779
反应条件
18-crown-6 ether in methanol T=60°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 51, # 23 p. 3041 - 3044
反应条件
in 1,4-dioxane T=90°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Wendt, Michael D.; Kunzer, Aaron R.
Tetrahedron Letters, 2010 , vol. 51, # 23 p. 3041 - 3044
反应条件
in 1,4-dioxane T=90°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Wendt, Michael D.; Kunzer, Aaron R.
Tetrahedron Letters, 2010 , vol. 51, # 23 p. 3041 - 3044
反应条件
in 1,4-dioxane T=90°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Wendt, Michael D.; Kunzer, Aaron R.
Tetrahedron Letters, 2010 , vol. 51, # 23 p. 3041 - 3044
反应条件
in methanol T=70°C; 24 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 51, # 23 p. 3041 - 3044
