2-{[(1,3-二甲基-1H-吡唑-5-基)氨基]亚甲基}丙二酸二乙酯合成路线 （共 4 条）
反应条件
T=120°C; Michael addition;
参考文献
Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4089 - 4100
反应条件
1: 77 percent / POCl3 / 18 h / 120 °C 2: 99 percent / potassium hydroxide / H2O; 1,2-dimethoxy-ethane / 18 h / 20 °C 3: SOCl2 / 1 h / 80 °C View Scheme
参考文献
Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 29 - 32
反应条件
trichlorophosphate 4 h; Heating;
参考文献
Canadian Journal of Chemistry, , vol. 66, # 3 p. 420-428
反应条件
1: 77 percent / POCl3 / 18 h / 120 °C 2: 99 percent / potassium hydroxide / H2O; 1,2-dimethoxy-ethane / 18 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 15 p. 4089 - 4100
