4-(2-氧代-5-苯基-1,2-二氢咪唑-3-基)哌啶-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: 1-t-butoxycarbonyl-4-aminopiperidine; α-bromoacetophenone With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 17 h; 2: cyanic acid sodium salt With acetic acid in dichloromethane T=0 - 20°C; pH=4; 16 h;
参考文献
Gutierrez, Corey; Termin, Andreas; Hadida-Ruah, Sara; Joshi, Pramod; Bergeron, Daniele; Yoo, Sanghee; Binch, Hayley; Come, Jon; Cao, Jingrong; Nanthakumar, Suganthi
Patent: US2008/4261 A1, 2008 ;
Location in patent: Page/Page column 137 ;
US 20080004261 A1
反应条件
1: 1-(1,1-dimethylethoxycarbonyl)-4-piperidinammonium hydrogencarbonate; α-bromoacetophenone With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 7 h; 2: cyanic acid sodium salt With acetic acid in dichloromethane cooling;
参考文献
Rudolf, Klaus; Eberlein, Wolfgang; Engel, Wolfhard; Pieper, Helmut; Entzeroth, Michael; Hallermayer, Gerhard; Doods, Henri
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5921 - 5931
参考文献
Dr. Karl Thomae GmbH
Patent: US6344/449 B1, 2002 ;
Location in patent: Example A1a) ;
Title/Abstract Full Text Show Details
Dr. Karl Thomae GmbH
Patent: US6344449 B1, 2002 ;
Location in patent: Example A1a) ;
参考文献
Dr. Karl Thomae GmbH
Patent: US6344/449 B1, 2002 ;
Location in patent: Example A1b) ;
Title/Abstract Full Text Show Details
Dr. Karl Thomae GmbH
Patent: US6344449 B1, 2002 ;
Location in patent: Example A1b) ;
