hydrogen; platinum(IV) oxide; ruthenium in dichloromethane T=20°C; P=760 Torr; 15 h;

manganese; cyclohexa-1,4-diene; 4-chloro-2,6-dimethylpyridine hydrochloride; ((1S,2R,5S)-2-i-Pr-5-Me-cyclohex-1-yl)Cp)2TiCl2 in tetrahydrofuran T=20°C; Title compound not separated from byproducts.;

1: 45 percent / CuI / diethyl ether / 1.17 h / -30 °C 2: 2,4,6-collidine hydrochloride; manganese; 1,4-cyclohexadiene / ((1S,2R,5S)-2-i-Pr-5-Me-cyclohex-1-yl)Cp)2TiCl2 / tetrahydrofuran / 20 °C View Scheme

1.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C 1.2: 82 percent / tetrahydrofuran; hexane / 20 °C 2.1: 87 percent / NaBH4; 1,2-diaminoethane; hydrogen / Ni(OAc)2*4H2O / methanol / 5 h / 20 °C 3.1: L-(+)-diethyl tartrate; Ti(i-PrO)4; TBHP / CH2Cl2 3.2: trimethylphosphite; 4-dimethylaminopyridine; triethylamine / CH2Cl2 4.1: 45 percent / CuI / diethyl ether / 1.17 h / -30 °C 5.1: 2,4,6-collidine hydrochloride; manganese; 1,4-cyclohexadiene / ((1S,2R,5S)-2-i-Pr-5-Me-cyclohex-1-yl)Cp)2TiCl2 / tetrahydrofuran / 20 °C View Scheme

1.1: L-(+)-diethyl tartrate; Ti(i-PrO)4; TBHP / CH2Cl2 1.2: trimethylphosphite; 4-dimethylaminopyridine; triethylamine / CH2Cl2 2.1: 45 percent / CuI / diethyl ether / 1.17 h / -30 °C 3.1: 2,4,6-collidine hydrochloride; manganese; 1,4-cyclohexadiene / ((1S,2R,5S)-2-i-Pr-5-Me-cyclohex-1-yl)Cp)2TiCl2 / tetrahydrofuran / 20 °C View Scheme

bis(cyclopentadienyl)titanium dichloride; sodium in benzene

lithium aluminium tetrahydride

iodosylbenzene; MnTTPPP(OAc) in benzene T=25°C; 7 h; other catalysts and regioselectivity investigated; Mechanism;

water in hexane; dichloromethane T=-23°C; 1 h; Yield given. Yields of byproduct given;

iron sulphate heptahydrate; mangabese(II) sulphate pentahydrate; air; D-glucose; calcium chloride in water T=25°C; pH=6.0; 168 h; Microbiological reaction; regioselective reaction;