(R)-3-羟甲基-1-甲基哌啶合成路线 （共 4 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 19 h; 2: With sodium hydroxide; water in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
BIOVITRUM AB (PUBL)
Patent: WO2009/71658 A1, 2009 ;
Location in patent: Page/Page column 33-34 ;
WO 2009/071658 A1
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6414148 B1, 2002 ;
US 6414148 B1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=20°C; 1.5 h;
参考文献
Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312
反应条件
1: 73 percent / HCOOH / 18 h / Heating 2: 94 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 20 °C View Scheme
参考文献
Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312
