(S)-2-[(苯基甲氧基)甲基]-4-(苯基甲基)吗啉合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in methanol; water T=0 - 40°C; 3.33333 h; 2: in methanol; water; toluene T=0 - 65°C; 3.16667 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/121685 A1, 2008 ;
Location in patent: Page/Page column 43-44 ;
WO 2008/121685 A1
反应条件
lithium aluminium tetrahydride in diethyl ether 0.666667 h; Ambient temperature;
参考文献
Berg, Stefan; Larsson, Lars-Gunnar; Renyi, Lucy; Ross, Svante B.; Thorberg, Seth-Olof; Thorell-Svantesson, Gun
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1934 - 1942
反应条件
1: 70 percent / 65 h / Ambient temperature 2: Na, MeOH / 4 h / Heating 3: 98 percent / LAH / diethyl ether / 0.67 h / Ambient temperature View Scheme
参考文献
Berg, Stefan; Larsson, Lars-Gunnar; Renyi, Lucy; Ross, Svante B.; Thorberg, Seth-Olof; Thorell-Svantesson, Gun
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1934 - 1942
反应条件
1: 70 percent / 65 h / Ambient temperature 2: Na, MeOH / 4 h / Heating 3: 98 percent / LAH / diethyl ether / 0.67 h / Ambient temperature View Scheme
参考文献
Berg, Stefan; Larsson, Lars-Gunnar; Renyi, Lucy; Ross, Svante B.; Thorberg, Seth-Olof; Thorell-Svantesson, Gun
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1934 - 1942
反应条件
1: Na, MeOH / 4 h / Heating 2: 98 percent / LAH / diethyl ether / 0.67 h / Ambient temperature View Scheme
参考文献
Berg, Stefan; Larsson, Lars-Gunnar; Renyi, Lucy; Ross, Svante B.; Thorberg, Seth-Olof; Thorell-Svantesson, Gun
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1934 - 1942
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=55 - 60°C; P=760 Torr; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1934 - 1942
