3-(4-苯基-1-哌嗪)-1-丙胺合成路线 （共 11 条）
反应条件
hydrogen; nickel in methanol P=3102.97 Torr; 12 h;
参考文献
Biswas, Swati; Zhang, Suhong; Fernandez, Fernando; Ghosh, Balaram; Zhen, Juan; Kuzhikandathil, Eldo; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 1 p. 101 - 117
反应条件
hydrazine in methanol T=20°C; 24 h;
参考文献
Nagarapu, Lingaiah; Mateti, Jhansi; Gaikwad, Hanmant K.; Bantu, Rajashaker; Sheeba Rani; Prameela Subhashini
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4138 - 4140
反应条件
1: 78 percent / triethylamine / acetonitrile / 7 h / Heating 2: methylamine / tetrahydrofuran; H2O / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 22 p. 7539 - 7550
反应条件
potassium carbonate in methanol; ethanol; water; acetone
参考文献
Synaptic Pharmaceutical Corporation
Patent: US5767131 A1, 1998 ;
反应条件
hydrogen bromide in acetic acid 1 h; Ambient temperature;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 6, # 6 p. 849 - 868
反应条件
hydrazine hydrate Multistep reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 18 p. 2399 - 2402
反应条件
nickel; dimethyl amine; benzene Hydrogenation;
参考文献
Yakugaku Zasshi, , vol. 76, p. 644,647, 648
Chem.Abstr., , p. 425
反应条件
nickel; benzene Hydrogenation;
参考文献
Yakugaku Zasshi, , vol. 76, p. 644,647, 648
Chem.Abstr., , p. 425
反应条件
1: Na2CO3 / 2-ethoxy-ethanol / 3 h / Heating 2: 1) KOH; 2) aq. NaOAc / 1) H2O, room temp., overnight; 2) H2O, a) 0 deg C, 2 h, b) room temp., 16 h 3: 1) HCl; 2) aq. alkaline sodium hyposulfite / 1) EtOH, reflux, 3 h; 2) toluene, room temp. View Scheme
参考文献
Boksa; Misztal; Chojnacka-Wojcik; Gastol-Lewinska; Grodecka; Mokrosz
Pharmazie, 1992 , vol. 47, # 4 p. 254 - 257
反应条件
1: in tetrahydrofuran T=20°C; 10 h; Inert atmosphere; 2: With bis(trichloromethyl) carbonate; potassium carbonate in tetrahydrofuran T=20°C; 10 h; Inert atmosphere;
参考文献
Li, Xin; Lee, Yong Rok; Kim, Sung Hong
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 9 p. 3480 - 3482
