5-甲氧基苯并[b]噻吩合成路线 （共 31 条）
反应条件
1.1: sec-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C 1.2: 79 percent / tetrahydrofuran; cyclohexane / -78 - 20 °C 2.1: 90 percent / CsF / dimethylformamide; H2O / Heating 3.1: 69 percent / LDA / tetrahydrofuran / -78 - 20 °C 4.1: 77 percent / NaBH4; NaOH / methanol; H2O / 13 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 26 p. 4767 - 4774
反应条件
1: 69 percent / LDA / tetrahydrofuran / -78 - 20 °C 2: 77 percent / NaBH4; NaOH / methanol; H2O / 13 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 26 p. 4767 - 4774
反应条件
1: 90 percent / CsF / dimethylformamide; H2O / Heating 2: 69 percent / LDA / tetrahydrofuran / -78 - 20 °C 3: 77 percent / NaBH4; NaOH / methanol; H2O / 13 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 26 p. 4767 - 4774
反应条件
1: I2, PPh3, imidazole 2: Na / ethanol 3: 1.) PIFA, BF3*Et2O, 2.) MeNH2 / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, H2O, r.t., 30 min 4: 88 percent / N-chlorosuccinimide View Scheme
参考文献
Synthesis, , # 5 p. 885 - 897
反应条件
1: Na / ethanol 2: 1.) PIFA, BF3*Et2O, 2.) MeNH2 / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, H2O, r.t., 30 min 3: 88 percent / N-chlorosuccinimide View Scheme
参考文献
Synthesis, , # 5 p. 885 - 897
反应条件
1: LiAlH4 / tetrahydrofuran 2: I2, PPh3, imidazole 3: Na / ethanol 4: 1.) PIFA, BF3*Et2O, 2.) MeNH2 / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, H2O, r.t., 30 min 5: 88 percent / N-chlorosuccinimide View Scheme
参考文献
Synthesis, , # 5 p. 885 - 897
反应条件
1: 100 percent / PPA / chlorobenzene 2: 64 percent / CuBr, MeONa / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 5 p. 759 - 764
反应条件
1: 37 percent / activated copper bronze / quinoline / 1 h / 210 - 220 °C 2: 76 percent / potassium carbonate / acetone / 2 h / 0 °C View Scheme
参考文献
Spectrochimica Acta - Part A Molecular and Biomolecular Spectroscopy, , vol. 57, # 14 p. 2795 - 2808
反应条件
1: 75 percent / iodine / tetrahydrofuran / 26 h / Heating 2: 37 percent / activated copper bronze / quinoline / 1 h / 210 - 220 °C 3: 76 percent / potassium carbonate / acetone / 2 h / 0 °C View Scheme
参考文献
Spectrochimica Acta - Part A Molecular and Biomolecular Spectroscopy, , vol. 57, # 14 p. 2795 - 2808
反应条件
1: 91 percent / sodium acetate / acetic acid; benzene / 4 h / Heating 2: 56 percent / sodium hydroxide / H2O / 0.5 h / 60 - 70 °C 3: 75 percent / iodine / tetrahydrofuran / 26 h / Heating 4: 37 percent / activated copper bronze / quinoline / 1 h / 210 - 220 °C 5: 76 percent / potassium carbonate / acetone / 2 h / 0 °C View Scheme
参考文献
Spectrochimica Acta - Part A Molecular and Biomolecular Spectroscopy, , vol. 57, # 14 p. 2795 - 2808
