(alphaS)-alpha-氨基-N-[(1R)-1-[(3aS,4S,6S,7aR)-六氢-3a,5,5-三甲基-4,6-甲桥-1,3,2-苯并二氧硼烷-2-基]-3-甲基丁基]苯丙酰胺盐酸盐合成路线 （共 3 条）
反应条件
hydrogenchloride in ethyl acetate T=-0.9 - 14.8°C; 4.55 h; Industry scale;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/97809 A2, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/097809 A2
反应条件
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine in dichloromethane T=-1.2 - 24.9°C; 2.18333 h; Industry scale;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/97809 A2, 2005 ;
Location in patent: Page/Page column 46-48 ;
WO 2005/097809 A2
反应条件
hydrogenchloride in ethyl acetate
T=-0.9 - 14.8°C; 4.55 h; Industry scale;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/97809 A2, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/097809 A2
