N-叔丁氧羰基-L-3,5-二氟苯丙氨酸合成路线 （共 5 条）
反应条件
1: 90 percent / NaOEt / ethanol / 2 h / Heating 2: 2M NaOH / methanol; H2O / 3 h / 40 °C 3: 92 percent / p-xylene / 2 h / Heating 4: Aspergillus genus acylase; 0.2 M AcONa; 0.2 M NaOH / H2O / 48 h / 38 °C / pH 8.0 5: 94 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
反应条件
1: Aspergillus genus acylase; 0.2 M AcONa; 0.2 M NaOH / H2O / 48 h / 38 °C / pH 8.0 2: 94 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
反应条件
1: 2M NaOH / methanol; H2O / 3 h / 40 °C 2: 92 percent / p-xylene / 2 h / Heating 3: Aspergillus genus acylase; 0.2 M AcONa; 0.2 M NaOH / H2O / 48 h / 38 °C / pH 8.0 4: 94 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
参考文献
Fujita, Tsugumi; Nose, Takeru; Matsushima, Ayami; Okada, Kazushi; Asai, Daisuke; Yamauchi, Yasuko; Shirasu, Naoto; Honda, Takeshi; Shigehiro, Daiki; Shimohigashi, Yasuyuki
Tetrahedron Letters, 2000 , vol. 41, # 6 p. 923 - 927
反应条件
1: 2-MeCDI
2: tetrahydrofuran
3: lithium hexamethyldisilazane / tetrahydrofuran
4: N-bromosuccinmide / tetrahydrofuran / -40 °C
5: sodium tetrahydroborate / ethanol / -78 °C
6: potassium hydroxide / ethanol
View Scheme
参考文献
Fustero, Santos; Cunat, Ana C.; Flores, Sonia; Baez, Claribel; Oliver, Judit; Cynamon, Michael; Guetschow, Michael; Mertens, Matthias D.; Delgado, Oscar; Tresadern, Gary; Trabanco, Andres A.
Chemistry - A European Journal, 2011 , vol. 17, # 52 p. 14772 - 14784
