3-(3-甲氧基苯基)-3-(三氟甲基)双吖丙啶合成路线 （共 11 条）
反应条件
silver(l) oxide in diethyl ether 20 h; in the dark;
参考文献
Blencowe, Anton; Cosstick, Kevin; Hayes, Wayne
New Journal of Chemistry, 2006 , vol. 30, # 1 p. 53 - 58
反应条件
1: 92 percent / NH2OH*HCl; C5H5N 2: 93 percent / C5H5N 3: 88 percent / NH3 4: 73 percent / I2; Et3N / methanol View Scheme
参考文献
Synlett, , # 2 p. 247 - 250
反应条件
1: 93 percent / C5H5N 2: 88 percent / NH3 3: 73 percent / I2; Et3N / methanol View Scheme
参考文献
Synlett, , # 2 p. 247 - 250
反应条件
1: 77 percent / n-BuLi 2: 92 percent / NH2OH*HCl; C5H5N 3: 93 percent / C5H5N 4: 88 percent / NH3 5: 73 percent / I2; Et3N / methanol View Scheme
参考文献
Synlett, , # 2 p. 247 - 250
反应条件
1: liq. NH3 / CH2Cl2 / 18 h / Ambient temperature 2: 77 percent / tert-butyl hypochlorite, Et3N / ethanol; 2-methyl-propan-2-ol / 2 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 2 p. 383 - 387
反应条件
1: 99 percent / KOH / tetrahydrofuran / 16 h 2: 88 percent / n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C 3: 97 percent / NH2OH*HCl; NaOH / ethanol / Heating 4: 98 percent / NEt3; DMAP / CH2Cl2 / 36 h / 20 °C / in the dark 5: 99 percent / NH3 / CH2Cl2 / 12 h / -78 °C 6: 98 percent / Ag2O / diethyl ether / 20 h / in the dark View Scheme
参考文献
New Journal of Chemistry, , vol. 30, # 1 p. 53 - 58
反应条件
magnesium oxide; lithium chloride; palladium dichloride; Tl(OCOCF3)3 1.) TFA, r.t., 24 h, 2.) r.t., 43 h; Yield given. Multistep reaction;
参考文献
Hatanaka, Yasumaru; Hashimoto, Makoto; Kurihara, Hiroko; Nakayama, Hitoshi; Kanaoka, Yuichi
Journal of Organic Chemistry, 1994 , vol. 59, # 2 p. 383 - 387
反应条件
1: 1.) thallium(III) trifluoroacetate, 2.) PdCl2, LiCl, MgO / 1.) TFA, r.t., 24 h, 2.) r.t., 43 h 2: 98 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C View Scheme
参考文献
Hatanaka, Yasumaru; Hashimoto, Makoto; Kurihara, Hiroko; Nakayama, Hitoshi; Kanaoka, Yuichi
Journal of Organic Chemistry, 1994 , vol. 59, # 2 p. 383 - 387
反应条件
1: 65 percent / titanium tetrachloride / CH2Cl2 / 1 h / Ambient temperature
2: 98 percent / Bu4NMnO4 / pyridine / 1 h / Ambient temperature
View Scheme
参考文献
Hashimoto, Makoto; Kanaoka, Yuichi; Hatanaka, Yasumaru
Heterocycles, 1997 , vol. 46, # 1 p. 119 - 122
反应条件
titanium tetrachloride in dichloromethane
1 h; Ambient temperature;
参考文献
Hashimoto, Makoto; Kanaoka, Yuichi; Hatanaka, Yasumaru
Heterocycles, 1997 , vol. 46, # 1 p. 119 - 122
