(3-硝基-5-三氟甲基)-苯甲酰胺合成路线 （共 4 条）
反应条件
ammonium hydroxide in tetrahydrofuran 18 h; Yield given;
参考文献
Sullivan, Robert W.; Bigam, Colin G.; Erdman, Paul E.; Palanki, Moorthy S. S.; Anderson, David W.; Goldman, Mark E.; Ransone, Lynn J.; Suto, Mark J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 413 - 419
反应条件
1: (COCl)2, DMF / CH2Cl2 / 18 h 2: NH4OH / tetrahydrofuran / 18 h View Scheme
参考文献
Sullivan, Robert W.; Bigam, Colin G.; Erdman, Paul E.; Palanki, Moorthy S. S.; Anderson, David W.; Goldman, Mark E.; Ransone, Lynn J.; Suto, Mark J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 413 - 419
反应条件
thionyl chloride; ammonia; trichlorophosphate in methanol; n-heptane; ethyl acetate; N,N-dimethyl-formamide; toluene
参考文献
Noro Nordisk A/S
Patent: US6503949 B1, 2003 ;
US 6503949 B1
反应条件
hydrogen; palladium on activated charcoal in ethanol
18 h;
参考文献
Sullivan, Robert W.; Bigam, Colin G.; Erdman, Paul E.; Palanki, Moorthy S. S.; Anderson, David W.; Goldman, Mark E.; Ransone, Lynn J.; Suto, Mark J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 413 - 419
