5-溴-2-氯-N-甲基嘧啶-4-胺合成路线 （共 2 条）
反应条件
in methanol T=0 - 20°C; 3.66667 h;
参考文献
Teno, Naoki; Gohda, Keigo; Wanaka, Keiko; Tsuda, Yuko; Sueda, Takuya; Yamashita, Yukiko; Otsubo, Tadamune
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2339 - 2352
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane in N,N-dimethyl-formamide
T=20 - 65°C; 16.33 h;
2: With potassium fluoride in diethyl ether; water; N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
IRM LLC; THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2006/135824 A1, 2006 ;
Location in patent: Page/Page column 13-14 ;
