4-(3-苯基丙基)吡啶合成路线 （共 12 条）
反应条件
nickel(II) bromide ethylene glycol dimethyl ether; bathophenanthroline; lithium hexamethyldisilazane in Sec-butyl alcohol T=60°C; Suzuki-Miyaura coupling; 16 h; Inert atmosphere;
参考文献
Molander, Gary A.; Argintaru, O. Andreea; Aron, Ioana; Dreher, Spencer D.
Organic Letters, 2010 , vol. 12, # 24 p. 5783 - 5785
反应条件
sodium hydroxide; n-butyllithium in tetrahydrofuran; water
参考文献
US6303593 B1, ;
US 6303593 B1
反应条件
bis(1,5-cyclooctadiene)nickel (0); (2,6-t-Bu2-4-Me-C6H2O)2AlMe; C{N(2,6-iPr2C6H3)CH}2 in toluene T=130°C; 9 h; Inert atmosphereAutoclave;
参考文献
Nakao, Yoshiaki; Yamada, Yuuya; Kashihara, Natsuko; Hiyama, Tamejiro
Journal of the American Chemical Society, 2010 , vol. 132, # 39 p. 13666 - 13668
反应条件
potassium hydroxide; hydrazine hydrate in various solvent(s) 120 deg C, 2 h then 160 deg C, 2 h, 195 deg C, 2 h;
参考文献
Reimann, Eberhard; Speckbacher, Johann; Lotter, Hermann
Archiv der Pharmazie (Weinheim, Germany), 1987 , vol. 320, # 5 p. 385 - 393
反应条件
T=250 - 350°C; P=15200 - 53200 Torr; 3 h;
参考文献
Il'yasov, E. A.; Galust'yan, G. G.; Kadyrov, Ch. Sh.
Chemistry of Natural Compounds, 1983 , vol. 19, # 1 p. 125
Khimiya Prirodnykh Soedinenii, 1983 , # 1 p. 122
反应条件
water; zinc in acetonitrile Inert atmosphereReflux; regioselective reaction;
参考文献
Mineyama, Kenji; Maekawa, Hirofumi; Kohsaka, Akihiro; Yamamoto, Yoshimasa; Nishiguchi, Ikuzo
Tetrahedron, 2009 , vol. 65, # 36 p. 7706 - 7711
反应条件
1: 1.) Mg / 1.) ether, 40 deg C, 1 h, 2.) room temp., 3 h then 40 deg C, 2 h 2: 88 percent / 80percent aq. NH2NH2*H2O, KOH / various solvent(s) / 120 deg C, 2 h then 160 deg C, 2 h, 195 deg C, 2 h View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 320, # 5 p. 385 - 393
反应条件
1: 1.) Mg / 1.) ether, 40 deg C, 1 h, 2.) room temp., 3 h then 40 deg C, 2 h 2: 88 percent / 80percent aq. NH2NH2*H2O, KOH / various solvent(s) / 120 deg C, 2 h then 160 deg C, 2 h, 195 deg C, 2 h View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 320, # 5 p. 385 - 393
反应条件
potassium; iron nitrate (III) in ammonia
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 1273 - 1280
反应条件
ammonia; KNH2 anschl. mit Phenaethylbromid;
参考文献
Journal of Organic Chemistry, , vol. 10, p. 452,456
