1: With 1H-imidazole in DMF (N,N-dimethyl-formamide) T=20°C; 4 h; 2: With hydrogen; palladium 10 on activated carbon in ethyl acetate P=2068.65 Torr; 18 h;
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: EP935598 B1, 2003 ;
Location in patent: Page 11-12 ;
EP 0935598 B1