1-甲基-1H-苯并咪唑-2-羧酸合成路线 （共 17 条）
反应条件
1: With water; sodium hydroxide in methanol T=50°C; 1 h; 2: With hydrogenchloride in water pH=2;
参考文献
AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
Location in patent: Page/Page column 171 ;
WO 2011/143365 A1
反应条件
1: 1-methyl-benzimidazole With n-butyllithium in diethyl ether; hexane T=-78 - -60°C; 0.5 h; 2: carbon dioxide With hydrogenchloride in diethyl ether; hexane T=-78 - -5°C; 1.16667 h;
参考文献
Betschmann, Patrick; Burchat, Andrew; Calderwood, David; Curtin, Michael L.; Davidsen, Steven K.; Davis, Heather M.; Frey, Robin R.; Heyman, Howard R.; Hirst, Gavin; Hrnciar, Peter; Michaelides, Michael; Rafferty, Paul
Patent: US2005/20619 A1, 2005 ;
Location in patent: Page 68 ;
US 20050020619 A1
反应条件
n-butyllithium; diethyl ether T=-60°C; Behandeln des Reaktionsgemisches mit festem CO2;
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1791
反应条件
1: carbon dioxide With [Au(1,3-bis(tert-butyl)imidazol-2-ylidene)(OH)]; potassium hydroxide in tetrahydrofuran T=20°C; P=1125.11 Torr; 0.25 h; 2: 1-methyl-benzimidazole in tetrahydrofuran T=20°C; P=1125.11 Torr; 12 h; 3: With hydrogenchloride in tetrahydrofuran; water regioselective reaction;
参考文献
Boogaerts, Ine I. F.; Nolan, Steven P.
Journal of the American Chemical Society, 2010 , vol. 132, # 26 p. 8858 - 8859
反应条件
1: 75 percent / 95percent NH2NH2 / methanol / Heating 2: 0.35 g / m-Chloroperbenzoic acid / acetic acid / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 12 p. 2518 - 2519
反应条件
3-chloro-benzenecarboperoxoic acid in acetic acid 0.5 h; Ambient temperature;
参考文献
Haddadin, Makhluf J.; Murad, Hiba H. N.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2518 - 2519
反应条件
potassium permanganate in water; acetone 4 h;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 12 p. 904 - 914
反应条件
1: 77 percent / 3 h / 170 - 180 °C 2: 96 percent / K2CO3; triethylbenzylammonium chloride / acetone / 3 h / 20 °C 3: KMnO4 / H2O; acetone / 4 h View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 12 p. 904 - 914
反应条件
1: 48 percent / 4 h / 170 - 180 °C 2: KMnO4 / H2O; acetone / 4 h View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 12 p. 904 - 914
反应条件
1: 96 percent / K2CO3; triethylbenzylammonium chloride / acetone / 3 h / 20 °C 2: KMnO4 / H2O; acetone / 4 h View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 12 p. 904 - 914
