1-(2-氨基-5-氯-3-甲氧基苯基)-2,2,2-三氟乙烷酮合成路线 （共 7 条）
反应条件
hydrogenchloride; sec.-butyllithium in tetrahydrofuran; ethylene glycol dimethyl ether; cyclohexane
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP929533 B1, 2003 ;
反应条件
1: s-BuLi / tetrahydrofuran / -20 - 0 °C 2: aq. HCl / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: SnCl2; EtOH / Heating 2: NEt3 / CH2Cl2 3: s-BuLi / tetrahydrofuran / -20 - 0 °C 4: aq. HCl / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: NEt3 / CH2Cl2 2: s-BuLi / tetrahydrofuran / -20 - 0 °C 3: aq. HCl / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1.1: BBr3 / CH2Cl2 2.1: imidazole / dimethylformamide / 0 °C 3.1: 76 percent / tetrahydrofuran; hexane / -20 °C 4.1: i-Pr2NEt / toluene / -25 - 20 °C 5.1: n-Bu4NF / tetrahydrofuran 5.2: chiral phase SCFC View Scheme
参考文献
Markwalder, Jay A.; Christ, David D.; Mutlib, Abdul; Cordova, Beverly C.; Klabe, Ronald M.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 619 - 622
反应条件
1: BBr3 / CH2Cl2 2: imidazole / dimethylformamide / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: BBr3 / CH2Cl2 2: imidazole / dimethylformamide / 0 °C 3: 76 percent / tetrahydrofuran; hexane / -20 °C 4: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Markwalder, Jay A.; Christ, David D.; Mutlib, Abdul; Cordova, Beverly C.; Klabe, Ronald M.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 619 - 622
