4-氯-2-三氟乙酰基-6-(叔丁基二甲基甲硅烷基氧基)苯胺合成路线 （共 8 条）
反应条件
in N,N-dimethyl-formamide
反应条件
1H-imidazole in N,N-dimethyl-formamide T=0°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: SnCl2; EtOH / Heating 2: NEt3 / CH2Cl2 3: s-BuLi / tetrahydrofuran / -20 - 0 °C 4: aq. HCl / 1,2-dimethoxy-ethane / Heating 5: BBr3 / CH2Cl2 6: imidazole / dimethylformamide / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: NEt3 / CH2Cl2 2: s-BuLi / tetrahydrofuran / -20 - 0 °C 3: aq. HCl / 1,2-dimethoxy-ethane / Heating 4: BBr3 / CH2Cl2 5: imidazole / dimethylformamide / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: s-BuLi / tetrahydrofuran / -20 - 0 °C 2: aq. HCl / 1,2-dimethoxy-ethane / Heating 3: BBr3 / CH2Cl2 4: imidazole / dimethylformamide / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: BBr3 / CH2Cl2 2: imidazole / dimethylformamide / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1.1: 76 percent / tetrahydrofuran; hexane / -20 °C 2.1: i-Pr2NEt / toluene / -25 - 20 °C 3.1: n-Bu4NF / tetrahydrofuran 3.2: chiral phase SCFC View Scheme
参考文献
Markwalder, Jay A.; Christ, David D.; Mutlib, Abdul; Cordova, Beverly C.; Klabe, Ronald M.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 619 - 622
反应条件
1: 76 percent / tetrahydrofuran; hexane / -20 °C 2: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Markwalder, Jay A.; Christ, David D.; Mutlib, Abdul; Cordova, Beverly C.; Klabe, Ronald M.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 619 - 622
