N-(3,4-二氟苯基)-2,2-二甲基丙酰胺合成路线 （共 2 条）
反应条件
triethylamine T=0 - 20°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2009/9015 A1, 2009 ;
Location in patent: Page/Page column 28-29 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -60 - -55 °C / |Molecular sieve; |Inert atmosphere 1.2: 3 h / -40 - 20 °C / |Molecular sieve; |Inert atmosphere 2.1: hydrogenchloride; sodium hydroxide / ethanol; diethyl ether / 24 h / |Molecular sieve; |Inert atmosphere View Scheme
参考文献
Yoshida, Yasuo; Hamada, Yusuke; Umezu, Kazuto; Tabuchi, Fumiya
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 958 - 961
