4-(叔丁氧羰基)苯甲 酸合成路线 （共 10 条）
反应条件
potassium hydroxide in tert-butyl alcohol
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US5232928 A1, 1993 ;
US 5232928 A
反应条件
chromium(VI) oxide; sulfuric acid in acetone cooling;
参考文献
Adlington; Baldwin; Becker; Chen; Cheng; Cooper; Hermann; Howe; McCoull; McNulty; Neubauer; Pritchard
Journal of Medicinal Chemistry, 2001 , vol. 44, # 10 p. 1491 - 1508
反应条件
4-(N,N-dimethlyamino)pyridine; di-tert-butyl dicarbonate in tetrahydrofuran 10 h; Heating;
参考文献
Mineno, Tomoko; Ueno, Tasuku; Urano, Yasuteru; Kojima, Hirotatsu; Nagano, Tetsuo
Organic Letters, 2006 , vol. 8, # 26 p. 5963 - 5966
反应条件
1: 62 percent / pyridine 2: 85 percent / NaOH / 2-methyl-propan-2-ol / 3 h / 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3852 - 3861
反应条件
1: 64 percent / benzene / 0.5 h / Heating 2: 84 percent / CrO3; aq.H2SO4 / acetone / cooling View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 10 p. 1491 - 1508
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran; tert-butyl alcohol 24 h; RefluxInert atmosphere;
参考文献
Kennedy, Andrew J.; Mathews, Thomas P.; Kharel, Yugesh; Field, Saundra D.; Moyer, Morgan L.; East, James E.; Houck, Joseph D.; Lynch, Kevin R.; MacDonald, Timothy L.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 10 p. 3524 - 3548
反应条件
1: 44 percent / CDI; HOBT / tetrahydrofuran 2: 67 percent View Scheme
参考文献
Seliger, H.; Bitar, M. B.; Goeldner, E.; Kittel, I.; Kilian, H. G.
Revue Roumaine de Chimie, 1991 , vol. 36, # 1-3 p. 171 - 186
反应条件
1: CDI; HOBT / tetrahydrofuran 2: CF3COOH / CHCl3 / 20 °C View Scheme
参考文献
Seliger, H.; Bitar, M. B.; Goeldner, E.; Kittel, I.; Kilian, H. G.
Revue Roumaine de Chimie, 1991 , vol. 36, # 1-3 p. 171 - 186
反应条件
triethylamine in tetrahydrofuran
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US5432178 A1, 1995 ;
反应条件
1: 92 percent / 4-dimethylaminopyridine; DCC / tetrahydrofuran / 3 h / 0 - 20 °C
2: 95 percent / H2 / 10 percent Pd/C / acetic acid
View Scheme
参考文献
Seliger, H.; Bitar, M. B.; Goeldner, E.; Kittel, I.; Kilian, H. G.
Revue Roumaine de Chimie, 1991 , vol. 36, # 1-3 p. 171 - 186
