2,4-二氧代-4-苯丁酸甲酯合成路线 （共 20 条）
反应条件
hydrazine hydrate; acetic acid T=118°C; 2 h;
参考文献
PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher
Patent: WO2014/20351 A1, 2014 ;
Location in patent: Page/Page column 36 ;
反应条件
1: hydroxylamine hydrochloride / methanol / 2 h / 50 °C 2: lithium hydroxide hydrate / tetrahydrofuran / 1 h / 50 °C 3: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C View Scheme
参考文献
Veeraswamy; Kurumurthy; Santhosh Kumar; Sambasiva Rao; Thelakkat, Kavya; Kotamraju, Srigiridhar; Narsaiah
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 9 p. 1369 - 1375
反应条件
1: 1,4-dioxane / 0.5 h / Reflux 2: chloroform / 1.83 h / 40 °C / Reflux View Scheme
参考文献
Mashevskaya; Mokrushin; Bozdyreva; Maslivets
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 2 p. 253 - 257
反应条件
1: hydroxylamine hydrochloride / methanol / 2 h / 50 °C 2: lithium hydroxide hydrate / tetrahydrofuran / 1 h / 50 °C View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
1: 51 percent / H2NNH2*H2O / ethanol / 5 h / Heating 2: 38 percent / LiAlH4 / tetrahydrofuran / 3.5 h / Ambient temperature View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1.1: sodium methylate / methanol / 0.25 h / 0 °C / |Green chemistry 1.2: 4 h / 0 °C / |Green chemistry 1.3: 2 h / |Reflux; |Green chemistry 2.1: methanol / 2 h / 110 - 112 °C / |Green chemistry View Scheme
参考文献
Lavanya; Narayan Reddy; Saritha Jyostna; Ramsubba Reddy
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 20, # 3 p. 279 - 280
反应条件
potassium carbonate in 1,4-dioxane; water
T=20°C; 10 h;
参考文献
Gein; Bezmaternykh; Voronina
Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 5 p. 254 - 256
反应条件
1: morpholine; isopropyl alcohol / 1 h / 35 °C
2: water; hydrogenchloride / 12 h / |Reflux
3: sulfuric acid / 8 h / |Reflux
View Scheme
参考文献
Sheverdov; Andreev, A. Yu.; Ershov; Nasakin; Tafeenko; Gein
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 7 p. 997 - 1005
Khim. Geterotsikl. Soedin., 2012 , # 7 p. 1073 - 1082,10
反应条件
1: acetic acid; NaNO2 / und anschliessendes Behandeln mit N2H4+H2O
2: PCl5; CHCl3
3: dioxane; methanol. NH3
4: aqueous K2CO3
5: beim Erhitzen
View Scheme
参考文献
Fusco; Rossi
Tetrahedron, 1958 , vol. 3, p. 209,218
Annali di Chimica (Rome, Italy), 1960 , vol. 50, p. 277,278
反应条件
1: morpholine; isopropyl alcohol / 1 h / 35 °C
2: water; hydrogenchloride / 12 h / |Reflux
View Scheme
参考文献
Sheverdov; Andreev, A. Yu.; Ershov; Nasakin; Tafeenko; Gein
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 7 p. 997 - 1005
Khim. Geterotsikl. Soedin., 2012 , # 7 p. 1073 - 1082,10
