2-（三甲基硅基）-2，2-二氟乙酸乙酯合成路线 （共 13 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; potassium fluoride T=50°C; 12 h;
参考文献
Bordeau, Michel; Frebault, Frederic; Gobet, Mallory; Picard, Jean-Paul
European Journal of Organic Chemistry, 2006 , # 18 p. 4147 - 4154
反应条件
potassium fluoride; copper(l) iodide in dimethyl sulfoxide T=60°C; 15 h; Inert atmosphere;
参考文献
Amii, Hideki; Fujikawa, Kenichi; Fujioka, Yasutaka; Matsuura, Makoto
Patent: US2012/220795 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1: chloro-trimethyl-silane With magnesium; copper(l) chloride; lithium chloride in N,N-dimethylimidazolidinone
T=25°C; 0.25 h; Inert atmosphere;
2: ethyl-α,α,α-trifluoroacetate in N,N-dimethylimidazolidinone
T=25°C; 4 h; Inert atmosphere;
3: With hydrogenchloride in ethanol
T=25°C; 1.5 h; Inert atmosphere;
参考文献
Utsumi, Shinya; Katagiri, Toshimasa; Uneyama, Kenji
Tetrahedron, 2012 , vol. 68, # 2 p. 580 - 583
反应条件
magnesium in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h; Inert atmosphere;
参考文献
Levin, Vitalij V.; Elkin, Pavel K.; Struchkova, Marina I.; Dilman, Alexander D.
Journal of Fluorine Chemistry, 2013 , vol. 154, p. 43 - 46
反应条件
magnesium in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Fujikawa, Kenichi; Fujioka, Yasutaka; Kobayashi, Akira; Amii, Hideki
Organic Letters, 2011 , vol. 13, # 20 p. 5560 - 5563
反应条件
tetrabutylammomium bromide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=-25°C; Electrochemical reaction;
参考文献
Bordeau, Michel; Clavel, Philipe; Barba, Alic; Berlande, Muriel; Biran, Claude; Roques, Nicolas
Tetrahedron Letters, 2003 , vol. 44, # 19 p. 3741 - 3744
反应条件
inox; tetrabutylammomium bromide; aluminium in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C; silylation; Electrochemical reaction;
参考文献
Clavel, Philippe; Biran, Claude; Bordeau, Michel; Roques, Nicolas; Trevinc, Stephane
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8763 - 8767
反应条件
tetrabutylammomium bromide; triethylamine in acetonitrile
T=50°C; Substitution; Electrochemical reactionPb cathode, C anode;
参考文献
Uneyama, Kenji; Mizutani, Go; Maeda, Kazushige; Kato, Tsuyoshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6717 - 6723
反应条件
tetrabutylammomium bromide; triethylamine in acetonitrile
T=0°C; Substitution; Electrochemical reactionPb cathode, C anode;
参考文献
Uneyama, Kenji; Mizutani, Go; Maeda, Kazushige; Kato, Tsuyoshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6717 - 6723
反应条件
tetraethylammonium tetrafluoroborate in acetonitrile
electrochemical reduction; Yields of byproduct given;
参考文献
Stepanov, Andrei A.; Minyaeva, Tatyana V.; Martynov, Boris I.
Tetrahedron Letters, 1999 , vol. 40, # 11 p. 2203 - 2204
