1: With sodium hydride in benzene T=60 - 111°C; 1.25 h; 2: With hydrogenchloride; water in methanol; benzene

1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=10 - 50°C; Inert atmosphere; 2: o-chloro benzoic acid chloride in acetonitrile T=0 - 70°C; Inert atmosphere; 3: With hydrogenchloride in water; acetonitrile pH=5 - 6;

1.1: thionyl chloride / 2 h / |Reflux 2.1: triethylamine; magnesium chloride / acetonitrile / 10 - 50 °C / |Inert atmosphere 2.2: 0 - 70 °C / |Inert atmosphere 2.3: pH 5 - 6 View Scheme

sodium T=100°C;

暂无反应条件数据

暂无反应条件数据

1: With sodium hydroxide in water 12 h; 2: With perchloric acid; sodium nitrite in water T=20°C; 14 h;