1: 1.) NaH 2: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 3: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 4: 84 percent / pyridine / 4 h / Ambient temperature 5: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 6: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature 7: 77 percent / p-TsOH / methanol / 5 h / Ambient temperature View Scheme

1: 1.) NaH 2: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 3: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C View Scheme

1: 1.) NaH 2: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 3: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 4: 84 percent / pyridine / 4 h / Ambient temperature 5: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 6: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature View Scheme

1: 1.) NaH 2: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 3: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 4: 84 percent / pyridine / 4 h / Ambient temperature 5: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h View Scheme