1: diethyl 2,2-bis(hydroxymethyl)malonate With hydrogen iodide
T=115 - 120°C; 6 h;
2: With potassium hydroxide
Inert atmosphere;
3: thiolacetic acid potassium salt With sulfuric acid in water
20 h;
参考文献
Venditti, Alessandro; Mandrone, Manuela; Serrilli, Anna Maria; Bianco, Armandodoriano; Iannello, Carmelina; Poli, Ferruccio; Antognoni, Fabiana
Journal of Agricultural and Food Chemistry, 2013 , vol. 61, # 28 p. 6848 - 6855
(1R)- (-)-10-camphorsulfonic acid in chloroform
72 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO KG
Patent: WO2004/65367 A1, 2004 ;
Location in patent: Page 129 - 130 ;
WO 2004/065367 A1
toluene-4-sulfonic acid in ethanol; benzene
1 h; Heating;
参考文献
MacCorquodale, Finlay; Walton, John C.; Hughes, Lise; Ingold, Keith U.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 12 p. 1893 - 1900