[3-(4-氯苯基)异噁唑-5-基]甲醇合成路线 （共 9 条）
反应条件
1: propargyl alcohol With pyridine; Novabiochem trityl chloride resin T=20°C; 48 h; 2: 4-chlorobenzaldehyde oxime With N-chloro-succinimide; triethylamine in dichloromethane T=20°C; 26 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.333333 h; Further stages.;
参考文献
De Luca; Giacomelli; Riu
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6823 - 6825
反应条件
potassium hydrogencarbonate; copper(II) sulfate; sodium L-ascorbate in water; tert-butyl alcohol T=20°C; 1.5 h;
参考文献
Wang, Xi-Zhao; Jia, Jiong; Zhang, Yan; Xu, Wei-Ren; Liu, Wei; Shi, Fang-Niu; Wang, Jian-Wu
Journal of the Chinese Chemical Society, 2007 , vol. 54, # 3 p. 643 - 652
反应条件
1: 4-chlorobenzaldehyde oxime With N-chloro-succinimide in N,N-dimethyl-formamide 3 h; 2: propargyl alcohol With CuSO4‵5H2O; potassium carbonate; ascorbic acid powder in N,N-dimethyl-formamide 1 h;
参考文献
Yin; Jia; Zhao; Xu; Tang; Wang
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 5 p. 695 - 703
反应条件
triethylamine in dichloromethane T=0 - 20°C; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 23 p. 4556 - 4566
反应条件
1: N-chlorosuccinimide / dimethylformamide / Ambient temperature 2: Et3N / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 23 p. 4556 - 4566
反应条件
1.1: hydroxylamine; pyridine / methanol / 20 °C 2.1: pyridine; Novabiochem trityl chloride resin / 48 h / 20 °C 2.2: N-chlorosuccinimide; triethylamine / CH2Cl2 / 26 h / 20 °C 2.3: 69 percent / TFA / CH2Cl2 / 0.33 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 20 p. 6823 - 6825
反应条件
in acetonitrile T=80°C; 2 h;
参考文献
Jadhav, Ravindra D.; Mistry, Hitesh D.; Motiwala, Hashim; Kadam, Kishorkumar S.; Kandre, Shivaji; Gupte, Amol; Gangopadhyay, Ashok K.; Sharma, Rajiv
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 4 p. 774 - 780
反应条件
jones reagent in acetone T=0 - 35°C; 3.5 h;
参考文献
Wang, Xi-Zhao; Jia, Jiong; Zhang, Yan; Xu, Wei-Ren; Liu, Wei; Shi, Fang-Niu; Wang, Jian-Wu
Journal of the Chinese Chemical Society, 2007 , vol. 54, # 3 p. 643 - 652
反应条件
1: triethylamine / dichloromethane / 11 h / 0 - 20 °C 2: sodium azide / N,N-dimethyl-formamide / 8 h / 55 °C 3: water; ammonium chloride; zinc / ethanol / 0.5 h / Reflux View Scheme
参考文献
Zhang, Datong; Jia, Jiong; Meng, Lijuan; Xu, Weiren; Tang, Lida; Wang, Jianwu
Archives of Pharmacal Research, 2010 , vol. 33, # 6 p. 831 - 842
