N-[(9H-芴-9-基甲氧基)羰基]-4-(磺基甲基)-L-苯丙氨酸合成路线 （共 17 条）
反应条件
sodium hydroxide; subtilisin in phosphate buffer T=20°C; 4 h;
参考文献
Herzner, Holger; Kunz, Horst
Tetrahedron, 2007 , vol. 63, # 28 p. 6423 - 6436
反应条件
ammonium formate; zinc in methanol
参考文献
Ali, Ahmed M.; Hill, Bryan; Taylor, Scott D.
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3583 - 3586
反应条件
1.1: 1,3-bis-(diphenylphosphino)-propane; triethylamine / Pd(OAc)2 / dimethylformamide / 0.17 h 1.2: 40 percent / trioctylsilane / dimethylformamide / 12 h / 70 °C 2.1: 72 percent / sodium borohydride / CH2Cl2; methanol / 0.67 h / 20 °C 3.1: 83 percent / triphenylphosphine; N-bromo-succinimide / tetrahydrofuran / 0 - 20 °C 4.1: 100 percent / sodium sulfite; H2O / dioxane / 1 h / 100 °C 5.1: 76 percent / subtilisin; aq. NaOH / aq. phosphate buffer / 4 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 28 p. 6423 - 6436
反应条件
1.1: 58 percent / triphenylphosphine; zinc / bis(triphenylphosphine)nickel bromide / acetonitrile / 1.5 h / 65 °C 2.1: aq. ammonia; hydrogen / Raney nickel / methanol / 3 h / pH 9 3.1: aq. HCl; sodium nitrite / dioxane / 1.5 h / pH 3 / Heating 3.2: 618 mg / aq. NaHCO3 / dioxane 4.1: 74 percent / triphenylphosphine; N-bromosuccinimide / tetrahydrofuran / 0 - 20 °C 5.1: 83 percent / sodium sulfite; H2O / dioxane / 1 h / Heating 6.1: aq. sodium carbonate / acetonitrile / 16 h / 20 °C 7.1: CH2Cl2; H2O / 2 h / 20 °C 8.1: 100.0 mg / triethylamine / H2O; acetonitrile / 0.5 h / 20 °C / pH 8.5 - 9.0 View Scheme
参考文献
Tetrahedron, , vol. 63, # 28 p. 6423 - 6436
反应条件
1.1: 81 percent / pyridine / CH2Cl2 / 0.67 h / 0 - 5 °C 2.1: 1,3-bis-(diphenylphosphino)-propane; triethylamine / Pd(OAc)2 / dimethylformamide / 0.17 h 2.2: 40 percent / trioctylsilane / dimethylformamide / 12 h / 70 °C 3.1: 72 percent / sodium borohydride / CH2Cl2; methanol / 0.67 h / 20 °C 4.1: 83 percent / triphenylphosphine; N-bromo-succinimide / tetrahydrofuran / 0 - 20 °C 5.1: 100 percent / sodium sulfite; H2O / dioxane / 1 h / 100 °C 6.1: 76 percent / subtilisin; aq. NaOH / aq. phosphate buffer / 4 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 28 p. 6423 - 6436
反应条件
1.1: aq. ammonia; hydrogen / Raney nickel / methanol / 3 h / pH 9 2.1: aq. HCl; sodium nitrite / dioxane / 1.5 h / pH 3 / Heating 2.2: 618 mg / aq. NaHCO3 / dioxane 3.1: 74 percent / triphenylphosphine; N-bromosuccinimide / tetrahydrofuran / 0 - 20 °C 4.1: 83 percent / sodium sulfite; H2O / dioxane / 1 h / Heating 5.1: aq. sodium carbonate / acetonitrile / 16 h / 20 °C 6.1: CH2Cl2; H2O / 2 h / 20 °C 7.1: 100.0 mg / triethylamine / H2O; acetonitrile / 0.5 h / 20 °C / pH 8.5 - 9.0 View Scheme
参考文献
Tetrahedron, , vol. 63, # 28 p. 6423 - 6436
反应条件
triethylamine in water; acetonitrile T=20°C; pH=8.5 - 9.0; 0.5 h;
参考文献
Herzner, Holger; Kunz, Horst
Tetrahedron, 2007 , vol. 63, # 28 p. 6423 - 6436
反应条件
1: 83 percent / sodium sulfite; H2O / dioxane / 1 h / Heating 2: aq. sodium carbonate / acetonitrile / 16 h / 20 °C 3: CH2Cl2; H2O / 2 h / 20 °C 4: 100.0 mg / triethylamine / H2O; acetonitrile / 0.5 h / 20 °C / pH 8.5 - 9.0 View Scheme
参考文献
Tetrahedron, , vol. 63, # 28 p. 6423 - 6436
反应条件
1: aq. sodium carbonate / acetonitrile / 16 h / 20 °C 2: CH2Cl2; H2O / 2 h / 20 °C 3: 100.0 mg / triethylamine / H2O; acetonitrile / 0.5 h / 20 °C / pH 8.5 - 9.0 View Scheme
参考文献
Tetrahedron, , vol. 63, # 28 p. 6423 - 6436
反应条件
1: CH2Cl2; H2O / 2 h / 20 °C 2: 100.0 mg / triethylamine / H2O; acetonitrile / 0.5 h / 20 °C / pH 8.5 - 9.0 View Scheme
参考文献
Tetrahedron, , vol. 63, # 28 p. 6423 - 6436
