1-叠氮基-4-甲基-2-硝基苯合成路线 （共 15 条）
反应条件
1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 3: conc. sulfuric acid / 0.25 h / 100 °C 4: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
Diazotization.Behandlung des Diazoniumperbromids mit Ammoniak;
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 2: conc. sulfuric acid / 0.25 h / 100 °C 3: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
参考文献
Forster; Barker
Journal of the Chemical Society, 1913 , vol. 103, p. 1922
反应条件
hydrogenchloride; sodium nitrite
参考文献
Zincke; Schwarz
Justus Liebigs Annalen der Chemie, 1899 , vol. 307, p. 43
反应条件
1: toluene / 2 h / Heating 2: triethyl phosphite / ethanol / 0.5 h / Heating 3: N-bromosuccinimide; benzoyl peroxide / CCl4 / 18 h / Heating View Scheme
参考文献
Deghati, Paymaneh Y. F.; Borghini, Alice; Van Den Nieuwendijk, Adrianus M. C. H.; Dissen-de Groote, Miriam; IJzerman, Adriaan P.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 6 p. 899 - 908
反应条件
1: acetic acid 2: HNO3, H2SO4 View Scheme
参考文献
Ghosh,P.B.; Whitehouse,M.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
反应条件
T=20°C; 168 h; PhotolysisNeat (no solvent);
参考文献
Leyva, Elisa; Leyva, Socorro; Gonzalez-Balderas, Regina M.; De Loera, Denisse; Jimenez-Catano, Rogelio
Mendeleev Communications, 2013 , vol. 23, # 4 p. 217 - 218
反应条件
diethyl 2-oxosuccinate sodium salt in ethanol T=50°C; 22 h; Further byproducts given;
参考文献
Bertelli, Lucia; Biagi, Giuliana; Giorgi, Irene; Manera, Clementina; Livi, Oreste; Scartoni, Valerio; Betti, Laura; Giannaccini, Gino; Trincavelli, Letizia; Barili, Pier Luigi
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 2 p. 113 - 122
