1: (2R)-3-Bromo-2-hydroxy-2-methylpropanoic Acid With thionyl chloride in isobutyramide T=-10°C; Inert atmosphere; 2: 4-amino-2-(trifluoromethyl)benzonitrile in isobutyramide T=20°C;

triethylamine in tetrahydrofuran T=20°C;

thionyl chloride; triethylamine in tetrahydrofuran; water

thionyl chloride; triethylamine in tetrahydrofuran; water

1: 3-bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione With hydrogenchloride Hydrolysis; Heating; 2: With thionyl chloride; dimethylammonium 2,4-dichlorophenoxyacetate T=-10 - -5°C; Chlorination; 3: 4-amino-2-(trifluoromethyl)benzonitrile With dimethylammonium 2,4-dichlorophenoxyacetate Acylation; Further stages. Title compound not separated from byproducts.;

1: N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-bromo-2-hydroxy-2-methylpropanamide With potassium carbonate in acetone 2 h; Reflux; 2: α-naphthol in isopropyl alcohol 18 h; Reflux;