6-溴-4-氯-3-喹啉羧酸乙酯合成路线 （共 5 条）
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=20°C; 3 h; Inert atmosphere;
参考文献
ELI LILLY AND COMPANY
Patent: US2012/184577 A1, 2012 ;
Location in patent: Page/Page column 2; 3 ;
反应条件
1: With trichlorophosphate T=180°C; 0.583333 h; Microwave irradiation; 2: With sodium hydroxide; water in dichloromethane
参考文献
ClanoTech AB
Patent: WO2009/63070 A2, 2009 ;
Location in patent: Page/Page column 13-14 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide 2 h; Reflux;
参考文献
Lopez Rivilli, Marisa J.; Moyano, Elizabeth L.; Yranzo, Gloria I.
Tetrahedron Letters, 2010 , vol. 51, # 3 p. 478 - 481
反应条件
1: ethanol / Reflux 2: diphenylether / Reflux 3: thionyl chloride / 17 h / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1448 - 1452
反应条件
1: ethanol / Reflux 2: diphenylether / Reflux 3: thionyl chloride / 17 h / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1448 - 1452
