7-溴-2,3-二氢苯并呋喃合成路线 （共 6 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-80°C; 0.5 h;
参考文献
Kerrigan, Frank; Martin, Claire; Thomas, Gerard H.
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2219 - 2222
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; Cooling with ethanol-dry ice;
参考文献
WO2005/58858 A1, ;
Page/Page column 168-169 ;
WO 2005/058858 A1
反应条件
1: 61 percent / aq. sodium hydroxide / 17 h / Heating 2: 86 percent / n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 15 p. 2219 - 2222
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-100°C;
2: With sulfur dioxide in tetrahydrofuran
T=-100 - -85°C; 2 h;
3: With N-chloro-succinimide in dichloromethane
T=0°C;
参考文献
Memory Pharmaceuticals Corporation
Patent: US2010/16297 A1, 2010 ;
Location in patent: Page/Page column 34 ;
US 20100016297 A1
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=117°C; 6 h;
参考文献
SCHWARZ PHARMA AG
Patent: EP1972628 A1, 2008 ;
Location in patent: Page/Page column 56-57 ;
EP 1972628 A1
反应条件
1: tri(o-tolyl)phosphine, bis(dibenzylideneacetone)palladium(O), sodium tert-butoxide / toluene / 100 °C
2: trifluoroacetic acid / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Kerrigan, Frank; Martin, Claire; Thomas, Gerard H.
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2219 - 2222
