2,2-二氟-2-(4-硝基苯基)乙酸合成路线 （共 6 条）
反应条件
1: copper(l) iodide; potassium fluoride / dimethyl sulfoxide / 15 h / 60 °C / Inert atmosphere 2: water; potassium carbonate / methanol / 2 h / 25 °C / Inert atmosphere View Scheme
参考文献
Amii, Hideki; Fujikawa, Kenichi; Fujioka, Yasutaka; Matsuura, Makoto
Patent: US2012/220795 A1, 2012 ;
反应条件
hydrogenchloride; water in diethyl ether 48 h; Heating; Yield given;
参考文献
Buss, Christopher W.; Coe, Paul L.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1998 , vol. 88, # 2 p. 111 - 116
反应条件
1: HgO, pyridinium poly(hydrogen fluoride) / 1.) 20 deg C, 1 h, 2.) 55 deg C, 1 h 2: HCl, H2O / diethyl ether / 48 h / Heating View Scheme
参考文献
Buss, Christopher W.; Coe, Paul L.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1998 , vol. 88, # 2 p. 111 - 116
反应条件
1: Cl2 / 48 h / 122 °C / Irradiation 2: HgO, pyridinium poly(hydrogen fluoride) / 1.) 20 deg C, 1 h, 2.) 55 deg C, 1 h 3: HCl, H2O / diethyl ether / 48 h / Heating View Scheme
参考文献
Buss, Christopher W.; Coe, Paul L.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1998 , vol. 88, # 2 p. 111 - 116
反应条件
potassium fluoride in N,N-dimethyl-formamide T=170°C; 3 h; Inert atmosphere;
参考文献
Fujikawa, Kenichi; Fujioka, Yasutaka; Kobayashi, Akira; Amii, Hideki
Organic Letters, 2011 , vol. 13, # 20 p. 5560 - 5563
反应条件
fluorine; silver nitrate in acetonitrile
T=-10°C; Inert atmosphere; ConcentrationTemperature;
参考文献
Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Veronique
Organic Letters, 2013 , vol. 15, # 11 p. 2648 - 2651
