4-(4-氨基苯)丁酸甲酯合成路线 （共 19 条）
反应条件
1: H2SO4 / Heating 2: trifluoroacetic anhydride, H2O2 / CH2Cl2 / 0.25 h / Heating 3: SF4, HF / 28 h 4: H2 / 10percent Pd/C / methanol; acetic acid / 20 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 84, # 2 p. 119 - 126
反应条件
1: 70 percent / AlCl3 / 1,2-dichloro-ethane 2: H2SO4 / Heating 3: trifluoroacetic anhydride, H2O2 / CH2Cl2 / 0.25 h / Heating 4: SF4, HF / 28 h 5: H2 / 10percent Pd/C / methanol; acetic acid / 20 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 84, # 2 p. 119 - 126
反应条件
1: SF4, HF / 28 h 2: H2 / 10percent Pd/C / methanol; acetic acid / 20 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 84, # 2 p. 119 - 126
反应条件
(i) aq. NaNO2, HCl, (ii) /BRN= 3587244/; Multistep reaction;
参考文献
Howe,I. et al.
Journal of the Chemical Society [Section] B: Physical Organic, 1969 , p. 439 - 445
反应条件
acetic acid in tetrahydrofuran T=110 - 120°C; 48 h; Yield given;
参考文献
Rapp, Maryse; Giraud, Isabelle; Maurizis, Jean-Claude; Madelmont, Jean-Claude
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5007 - 5012
反应条件
1: AcOH / tetrahydrofuran / 48 h / 110 - 120 °C 2: POCl3 / benzene / 1 h / Heating 3: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min 4: EtOCOCl, Et3N / acetone / 0.25 h / 0 °C 5: aq. NaN3 / acetone / 0.5 h / 0 °C 6: benzene / 1 h / Heating 7: 8 N HCl / 0.17 h / Heating 8: 76 percent / methanol / 24 h / 20 °C View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
反应条件
1: acetic acid
2: phosphorus oxychloride / toluene / Heating
View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
反应条件
1: AcOH / tetrahydrofuran / 48 h / 110 - 120 °C
2: POCl3 / benzene / 1 h / Heating
3: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min
4: EtOCOCl, Et3N / acetone / 0.25 h / 0 °C
5: aq. NaN3 / acetone / 0.5 h / 0 °C
6: benzene / 1 h / Heating
View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
反应条件
acetic acid
Erwaermen des Reaktionsprodukts mit POCl3 in Benzol und Erhitzen des erhaltenen Esters mit konz. wss. HCl;
参考文献
Everett et al.
Journal of the Chemical Society, 1953 , p. 2386,2387
