反应条件
1.1: toluene; tetrahydrofuran / 12 h / 0 °C / |Inert atmosphere
2.1: N-bromosuccinmide / N,N-dimethyl-formamide / 0.5 h / 20 °C / |Inert atmosphere
3.1: copper(I) oxide; potassium carbonate / pyridine / 2 h / 20 °C / |Inert atmosphere
3.2: 17 h / 20 °C / |Inert atmosphere
4.1: water / N,N-dimethyl-formamide; methanol / 20 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Ueda, Kazunori; Yamashita, Mitsuaki; Sakaguchi, Koichi; Tokuda, Harukuni; Iida, Akira
Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 6 p. 648 - 654