2-(甲基硫代)-5-甲基嘧啶-4(1H)-酮合成路线 (共 7 条)
反应条件
potassium hydroxide; tetrabutylammomium bromide in water; dimethyl sulfoxide
参考文献
Karl Thomae GmbH
Patent: US6114390 A1, 2000 ;
US 6114390 A
反应条件
potassium hydroxide in ethanol 2 h; Heating;
参考文献
Youssef, Mohamed M.; Youssef, Ayman M. S.
Phosphorus, Sulfur and Silicon and the Related Elements, 2003 , vol. 178, # 1 p. 67 - 81
反应条件
triethylamine in tetrahydrofuran T=25°C; 5 h; Yield given. Yields of byproduct given;
参考文献
Perez, Caroline; Janin, Yves L.; Adams, David R.; Monneret, Claude; Grierson, David S.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 901 - 911
参考文献
Brooks et al.
Journal of the Chemical Society, 1950 , p. 452,456
反应条件
1: 60 percent / POCl3 / dioxane / 2 h / Heating 2: 30 percent / aq. NH3 / 2 h / Heating View Scheme
参考文献
Youssef, Mohamed M.; Youssef, Ayman M. S.
Phosphorus, Sulfur and Silicon and the Related Elements, 2003 , vol. 178, # 1 p. 67 - 81
反应条件
in 1,3-dimethyl-imidazolidin-2-one T=170°C; 72 h; Heating / reflux;
参考文献
TARGEGEN INC.
Patent: WO2009/46416 A1, 2009 ;
Location in patent: Page/Page column 76 ;
WO 2009/046416 A1
反应条件
trichlorophosphate
T=120°C; 2 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1754706 A1, 2007 ;
Location in patent: Page/Page column 94 ;