2-氨基-5-溴-3-甲基苯甲酸甲酯合成路线 （共 7 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
WO2011/8572 A2, ;
Page/Page column 70-71 ;
WO 2011/008572 A2
反应条件
bromine in acetic acid T=20°C; 0.5 h;
参考文献
Helvetica Chimica Acta, , vol. 87, # 6 p. 1333 - 1356
参考文献
US5929097 A1, ;
US 5929097 A
反应条件
1: hydrogen bromide / water; dimethyl sulfoxide / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 20 °C View Scheme
参考文献
WO2011/8572 A2, ;
WO 2011/008572 A2
反应条件
in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
Chinese Journal of Chemistry, , vol. 30, # 8 p. 1748 - 1758
反应条件
1: acetic anhydride; 2-Amino-5-bromo-3-methyl-benzoic acid methyl ester With potassium acetate in chloroform T=0 - 20°C; 0.25 h; 2: isopentyl nitrite With 18-crown-6 ether in chloroform T=65°C; 18 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 22, # 3 p. 1156 - 1162
反应条件
1.1: potassium acetate / chloroform / 0.25 h / 0 - 20 °C 1.2: 18 h / 65 °C 2.1: hydrogenchloride / water; methanol / 2 h / 20 °C View Scheme
参考文献
Kim, Mi Kyoung; Shin, Heerim; Cho, Seo Young; Chong, Youhoon
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 1156 - 1162
