4-(2-氨基-4-噻唑基)苯甲酸甲酯合成路线 （共 7 条）
反应条件
sodium carbonate in isopropyl alcohol 0.583333 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 109 ;
反应条件
sodium carbonate; thiourea in water; isopropyl alcohol
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
1: iodine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C 2: dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 5 p. 1093 - 1101
参考文献
Annadurai, Sivakumar; Martinez, Rogelio; Canney, Daniel J.; Eidem, Tess; Dunman, Paul M.; Abou-Gharbia, Magid
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7719 - 7725
反应条件
in dichloromethane; N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Donohoe, Timothy J.; Kabeshov, Mikhail A.; Rathi, Akshat H.; Smith, Ian E. D.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 5 p. 1093 - 1101
反应条件
1: toluene; methanol; hexane / 0.33 h / 0 °C 2: iodine / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 24 p. 7719 - 7725
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; methanol; water; N,N-dimethyl-formamide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 110 ;
