2-氨基-6-溴-4-甲氧基苯酚合成路线 （共 4 条）
反应条件
hydrogen in tetrahydrofuran P=1292.87 Torr; 2.5 h;
参考文献
Wyeth
Patent: US2006/46968 A1, 2006 ;
Location in patent: Page/Page column 27 ;
反应条件
1: bromine; NaOAc; AcOH / 2.5 h / 20 - 70 °C 2: 96 percent / H2 / tetrahydrofuran / 2.5 h / 1292.87 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5021 - 5040
参考文献
US2004/92512 A1, ;
Page 28 ;
US 20040092512 A1
反应条件
1: 46.5 g / pyridine / CH2Cl2 / 0 °C 2: 81 percent / p-toluenesulfonic acid monohydrate; p-xylene / 3 h / Heating 3: 93 percent / BBr3 / CH2Cl2 / -78 - 20 °C 4: 72 percent / dichlorobis(tri-o-tolylphosphine)palladium (II) / 1,2-diethoxy-ethane / 48 h / 115 °C View Scheme
参考文献
Malamas, Michael S.; Manas, Eric S.; McDevitt, Robert E.; Gunawan, Iwan; Xu, Zhang B.; Collini, Michael D.; Miller, Chris P.; Dinh, Tam; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5021 - 5040
