5-二甲基氨基-2-硝基苯胺合成路线 （共 13 条）
反应条件
1: With triethylamine in ethanol T=130°C; P=3000.3 Torr; 20 h; 2: With sodium hydroxide in water
参考文献
CURIS, INC.
Patent: WO2006/50506 A1, 2006 ;
Location in patent: Page/Page column 111 ;
反应条件
potassium carbonate in water; N,N-dimethyl-formamide T=150°C; 12 h;
参考文献
PETER MACCALLUM CANCER INSTITUTE; MARTIN, Roger, Francis; WHITE, Jonathan; LOBACHEVSKY, Pavel; WINKLER, David; SKENE, Colin; MARCUCCIO, Sebastian
Patent: WO2011/123890 A1, 2011 ;
Location in patent: Page/Page column 99 ;
反应条件
sodium carbonate T=50°C; 8 h;
参考文献
Cazaux, Louis; Faher, Mourad; Picard, Claude; Tisnes, Pierre
Canadian Journal of Chemistry, 1993 , vol. 71, # 8 p. 1236 - 1246
反应条件
potassium carbonate in N,N-dimethyl-formamide 4.5 h; Heating;
参考文献
Harapanhalli; McLaughlin; Howell; Rao; Adelstein; Kassis
Journal of medicinal chemistry, 1996 , vol. 39, # 24 p. 4804 - 4809
反应条件
ethanol; sodium acetate T=100°C; unter Druck;
参考文献
Arcos; Miller
Journal of the American Chemical Society, 1955 , vol. 77, p. 3128
反应条件
ethanol; sodium acetate T=100°C; unter Druck;
参考文献
Arcos; Miller
Journal of the American Chemical Society, 1955 , vol. 77, p. 3128
反应条件
1-methyl-piperazine; potassium carbonate 4.5 h; Heating;
参考文献
Harapanhalli; McLaughlin; Howell; Rao; Adelstein; Kassis
Journal of medicinal chemistry, 1996 , vol. 39, # 24 p. 4804 - 4809
反应条件
potassium carbonate; 6-amino-hexanoic acid 25 h; Heating;
参考文献
Kuznetsov, V. A.; Garabadzhiu, A. V.; Ginzburg, O. F.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, p. 576 - 580
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 3 p. 637 - 642
参考文献
van Romburgh
Recueil des Travaux Chimiques des Pays-Bas, 1923 , vol. 42, p. 805
反应条件
1: HNO3+H2SO4 / 0 °C 2: alcohol; ammonia / 120 °C View Scheme
参考文献
van Romburgh
Recueil des Travaux Chimiques des Pays-Bas, 1923 , vol. 42, p. 805
