(R)-(-)-扁桃酸甲酯合成路线 (共 107 条)
反应条件
n-butyllithium in diethyl ether; hexane 1.5 h; Heating;
参考文献
Weber, Edwin; Hager, Orm; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L.
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 1 p. 50 - 60
参考文献
Braun, Manfred; Devant, Ralf
Tetrahedron Letters, 1984 , vol. 25, # 44 p. 5031 - 5034
反应条件
1.1: immobilized penicillin G acylase mutant 1 / water / 2 °C / pH 8.5 / |Enzymatic reaction 1.2: pH 4.3 2.1: 1H-imidazole / isopropanol acetate / 8 h / 20 °C 2.2: pH 2 3.1: sodium 2-ethyl hexanoate / isopropyl alcohol; acetone / 20 °C / pH 5.6 View Scheme
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas
Patent: WO2013/57197 A1, 2013 ;
参考文献
McKenzie; Wren
Journal of the Chemical Society, 1919 , vol. 115, p. 609
反应条件
1: 1.) Mg, I2 / 1.) THF, reflux, 3 h; 2.) THF, reflux, 3-5 h 2: 90 percent / pyridine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Braun, Manfred; Devant, Ralf
Tetrahedron Letters, 1984 , vol. 25, # 44 p. 5031 - 5034
反应条件
3G3K penicillin G acylase immobilized on glyoxyl agarose T=4°C; pH=6.5; aq. phosphate bufferEnzymatic reaction;
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas
Patent: WO2013/57197 A1, 2013 ;
Location in patent: Page/Page column 8 ;
反应条件
immobilized penicillin G acylase from Escherichia coli in phosphate buffer T=4°C; pH=6.5; Kinetics;
参考文献
Terreni, Marco; Tchamkam, Joseph Gapesie; Sarnataro, Umberto; Rocchietti, Silvia; Fernandez-Lafuente, Roberto; Guisan, Jose M.
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 1 p. 121 - 128
参考文献
McKenzie; Wren
Journal of the Chemical Society, 1919 , vol. 115, p. 609
反应条件
e.e. = 76percent; Multistep reaction. Title compound not separated from byproducts;
参考文献
Feenstra, R. W.; Stokkingreef, E. H. M.; Nivard, R. J. F.; Ottenheijm, H. C. J.
Tetrahedron Letters, 1987 , vol. 28, # 11 p. 1215 - 1218
反应条件
sodium tetrahydroborate in methanol T=20°C; 0.5 h;
参考文献
Atobe, Masakazu; Yamazaki, Naoki; Kibayashi, Chihiro
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5595 - 5607