(R)-(-)-扁桃酸甲酯合成路线 （共 107 条）
反应条件
1: 97 percent / NaBH4 / methanol / 0.5 h / 20 °C 2: 81 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 48 h / 20 °C 3: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating 4: 99 percent / TsOH / toluene / 0.5 h / Heating 5: toluene; diethyl ether / 0.42 h / 0 °C 6: zinc / acetic acid; tetrahydrofuran; H2O / 4 h / 60 °C View Scheme
参考文献
Atobe, Masakazu; Yamazaki, Naoki; Kibayashi, Chihiro
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5595 - 5607
反应条件
3G3K penicillin G acylase immobilized on glyoxyl agarose T=4°C; pH=6.5; aq. phosphate bufferEnzymatic reaction;
参考文献
Serra, Immacolata; Ceechini, Davide A.; UbiaIi, Daniela; Manazza, Elena M.; Albertini, Alessandra M.; Terreni, Marco
European Journal of Organic Chemistry, 2009 , # 9 p. 1384 - 1389
反应条件
immobilized penicillin G acylase from Escherichia coli in methanol; phosphate buffer T=4°C; pH=5.5; 4 h; Product distributionKinetics; Further Variations:pH-valuesSolvents;
参考文献
Terreni, Marco; Tchamkam, Joseph Gapesie; Sarnataro, Umberto; Rocchietti, Silvia; Fernandez-Lafuente, Roberto; Guisan, Jose M.
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 1 p. 121 - 128
参考文献
McKenzie; Wren
Journal of the Chemical Society, 1919 , vol. 115, p. 609
参考文献
McKenzie; Wren
Journal of the Chemical Society, 1919 , vol. 115, p. 609
反应条件
1: 97 percent / ammonia gas / methanol / 22 h 2: 78 percent / LiAlH / tetrahydrofuran / 1.) reflux, 8 h, 2.) r.t., overnight View Scheme
参考文献
Wu, Shao-Yong; Hirashima, Akinori; Takeya, Ryuko; Eto, Morifusa
Agricultural and Biological Chemistry, 1989 , vol. 53, # 1 p. 165 - 174
反应条件
e.e. = 76percent; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 28, # 11 p. 1215 - 1218
