(R)-(-)-扁桃酸甲酯合成路线 （共 107 条）
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate in chloroform T=35°C; 24 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 3 p. 428 - 433
反应条件
1: 95 percent / H2SO4 / H2O / 0.5 h / 90 °C 2: 90 percent View Scheme
参考文献
Tetrahedron, , vol. 54, # 48 p. 14549 - 14564
反应条件
1: KBH4 / methanol / 10 h / 0 °C 2: 95 percent / H2SO4 / H2O / 0.5 h / 90 °C 3: 90 percent View Scheme
参考文献
Tetrahedron, , vol. 54, # 48 p. 14549 - 14564
反应条件
anhydrous magnesium perchlorate; 4S,11R-Me3MQPH (obtained by PNAH reduction) in acetonitrile 24 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 42, # 4 p. 961 - 974
反应条件
1: 4-methyl-1,3-dioxolan-2-one; hydrogenchloride / water / 6 h / Reflux 2: sulfuric acid / toluene / 4 h / Reflux View Scheme
参考文献
Beilstein Journal of Organic Chemistry, , vol. 6, p. 1043 - 1055
反应条件
anhydrous magnesium perchlorate in acetonitrile Reduction; 0.0833333 h;
参考文献
Tetrahedron Letters, , vol. 41, # 7 p. 1035 - 1038
反应条件
1: 94 percent / TsOH / CH2Cl2 2: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. LiOH / 1.) CH2Cl2, 0 deg C, 15 min, 2.) THF, from 0 deg C to RT 3: 90 percent / Hg(OCOCF3)2, BF3*OEt2 View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 14 p. 1653 - 1654
反应条件
1: TosOH, molecular sieve 4 Angstroem / diethyl ether / 1 h / Ambient temperature 2: 75 percent / HCl / diethyl ether / 5 °C 3: 84 percent / 0.2 N HCl / diethyl ether View Scheme
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1591 - 1606
反应条件
1: 75 percent / HCl / diethyl ether / 5 °C 2: 84 percent / 0.2 N HCl / diethyl ether View Scheme
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1591 - 1606
反应条件
sulfuric acid in toluene 4 h; Reflux;
参考文献
Beilstein Journal of Organic Chemistry, , vol. 6, p. 1043 - 1055
